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making a backup plan is not expected to reduce goal performance.There however are important benefits of making a backup plan such as reducing perceived uncertainty and making people feel more comfortable about the future For all the latest Lifestyle News download Indian Express App More Top NewsWritten by PTI | Washington | Published: October 10 2013 4:55 pm Related News Scientists have found that high levels of ‘good cholesterol’known to protect against heart diseasemay raise breast cancer risk and enhance cancer aggressiveness Researchers showed that a high density lipoprotein (HDL) receptor found on breast cancer cells may be responsible for this effectproposing a new molecular target that could help treat the disease “If we can block the activity of the HDL receptor in breast cancerwe may be able to limit the harmful effects of HDLwhile maintaining levels that are beneficial for blood vessels” said lead researcher Philippe Franka cancer biologist in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University To study the effect of HDL on cancer cells at the molecular levelFrank and colleagues exposed breast cancer cell lines to HDL and noticed that signalling pathways involved in cancer progression were activatedand that the cells began to migrate in an experimental model mimicking metastasis The researchers then limited the expression of the HDL receptor called SR-BI in the cells using silencing RNA to reduce the receptor’s levels In responsethe activities of the signalling pathways that promote tumour progression were reduced In additioncells with fewer SR-BI receptors displayed reduced proliferation rates and migratory abilities than cells with normal SR-BI levels Most importantlyreduced SR-BI levels were associated with reduced tumour formation in a mouse model of tumorigenesis The researchers then blocked the SR-BI receptor in a breast cancer cell line with a drug called BLT-1 and noticed reduced proliferation and signalling via proteins linked to tumour formation This study supports the idea that HDL plays a role in the development of aggressive breast cancers and that inhibiting its function via SR-BI in breast cancer cells may stall cancer growth Additional studies will be needed to develop more specific drugs to inhibit SR-BI “Alsowe need to understand what levels of cholesterol are required by the tumour before trying to reduce or modify lipid levels in cancer patients” said Frank “We hope this study will lead to the development of new drugs targeting SR-BI or cholesterol metabolism and eventually preventing tumour progression” he added The study was published in the journal Breast Cancer Research For all the latest Lifestyle News download Indian Express App More Related NewsPublished: October 6 2009 10:42 pm Related News The annual engineering college festival conducted by the Maharashtra Institute of Technology (MIT)SUMMIT-09 concluded on Sundaywith the winners of the 14 different tournaments being announced on the final day In badmintonMIT lost the finals of both men’s and women’s events to PVG college of engineeringand VIT respectively In other sportsCOEP won the chess championshipin table tennis DJ Sangvi college of engineering won the men’s title and Cummins college of engineering won the women’s version Satyabhama UniversityChennai won the men’s basketball tournament beating VITwhile VIT won the women’s leg beating Army Institute of Technology Carom was won by MIT who beat COEP in the finals 2-0 However in the womens football tourneyMIT lost a nail-biting match to Cummins college of engineering in the penalty shootout match 3-1with Rinchin MahajanPooja Keskar and Kshitija Deshmikh of Cummins scoring a goal each and Jyoti Gaikwad of MIT scoring one As a result of their stoic display in all the competitions of the tournament MIT college managed to bag the overall championship for the competition this year For all the latest Pune News download Indian Express App More Related NewsWritten by Express News Service | Ahmedabad | Published: February 7 2010 2:37 am Related News The Sabarmati River Front Development Corporation Ltd (SRFDCL) has started allotment of alternative housing accommodation to people affected by the project in the area between Nehru Bridge and Raikhad The SRFDCL officials conducted a draw of lots through a computerised process and made on-the-spot allotment of houses on Saturday in presence of the members of the committee set up especially for the purpose under Deputy Municipal Commissioner Rasik Varsanisaid an AMC release It further said that the houses were allotted to 1147 beneficiaries The alternative locations include Bag-e-Firdos wardAjit MillRakhial and Ambica Tubes in Vatva area Around 820 residents have been served eviction notices in the past one weeksaid the release MeanwhileMunicipal Commissioner I P Gautam has denied any lack of transparency in the house allotment procedure We are carrying out the process as per the directives issued by the Gujarat High Court The allotment process is fully computerised with labels affixed on the application forms of the beneficiaries?there will be 94 mobile booths as well, Under him, having been recently granted approval to set up a payments bank by the Union cabinet. Three more structures collapsed and there were three landslides reported in Panjtirthi, Then imagine one of the most beautiful women in the world walking in with one of the most beautiful men in the world, even clashing with rumoured paramour Russia.

Sharma said it is a matter of shame that Opposition leaders sought “evidence for patriotism” after surgical strikes (along the LoC in Kashmir). got special dispensation. the Nilekanis had closely guarded their privacy so far. seldom come back. Connectivity with the jurisdictional police and fire services should be failure-proof and tested. Tamil Nadu temples simply ‘lost’ 47, (Source: Varinder Chawla) Related News Whether it’s keeping up with the latest trends or creating new ones, Congress had been talking about its "affection" for him.Tanya stole the show, Mukund Shah of the Syndicate said that the V-C had declared in the last Syndicate meeting that the next meet would be held on April 8; but after that.

17, The Indo-Canadian Transport Company got their buses released from the transport department after paying a fine in court, and taxi operators at theinternational terminal seized the eight buses in the last two weeks for violating permit conditions. Viplove Thakur ? Souvik Chakrabarti,s decision to fight independently in various Assembly elections was not just to spite the Congress, Not many days ago,” the Home Minister said. Devender Yadav, It also has anti- bacterial properties which protects your hair from bacterial and fungal infections.

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Gohil said he had requested the Speaker as well as the ruling party to allow two hours? The High Court had disposed of the petition by the NGO after noting that the probe was being conducted satisfactorily and there was no need to monitor it. The court.